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After stroke, uninvolved brain regions reorganize the location of their areas of somatic control for the purpose of taking on brain functions lost as a result of cerebral infarction. Identifying imaging parameters corresponding to cerebral reorganization and demonstrating an association between neurological recoveries with ongoing cerebral reorganization will result in a better understanding of the stroke recovery process. This study will employ neuroimaging techniques [positron emission tomography (PET) and magnetic resonance (MR) imaging] to investigate cerebral reorganization after cerebral infarction. Longitudinal neuroimaging measures will be correlated with patient functional recovery.
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Neuroimaging and Stroke Rehabilitation Prognosis
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Risk Factors and Potential Causes of Eustachian Tube Dysfunction in Adults with Clinically Diagnosed Chronic Otitis Media with Effusion and/or Eustachian Tube Dysfunction
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Adults aged 18 years and older with a tympanostomy tube (small plastic-like tube) in their eardrum are needed for a research study of Eustachian tube problems. Study participation requires 1 visit (˜2 to 3 hours) to the Middle Ear Physiology Laboratory in Oakland, part of the Ear Nose and Throat Research Center of Children’s Hospital of UPMC. Volunteers are reimbursed for participation. Interested persons should call 412-692-3595 for more information or 412-692-3597 for a recorded study description.
A randomized, double blind crossover pilot study of the efficacy of immunotherapy in prick negative intradermal positive patients with allergic rhinitis
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To determine whether subjects whose allergies are not detectable by skin multiprick testing but are evident on intradermal dilutional testing (IDT) have improvement in allergy symptoms after 6 months of weekly allergy shots compared to a placebo control group.
Emphysema Research Registry and Biosample Repository – Registry
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The Emphysema / COPD Research Cente (ECRC) is a specialty center whose mission is to advance out understanding of emphysema and tobacco-related lung disease and to evaluate new therapies for patients with emphysema. The centerpiece of the ECRC is the Registry, a froup of interested patiens with Chronic Obstructive Pulmonary Disease (COPD) who wish to be notified of new trials for which they may qualify. Registry patients participate in the collection of information about their disease, including completing basic screening questionnairs (which also involves the examination of your medical records with your authorization), lung finction testing, and a blood sample. The registry patients have allowed the ECRC to be a national leader in the discovery of new understanding and treatment options for patients with emphysema and COPD.
Carotid Revascularization Endarterectomy vs. Stent Trial
Brief description of the study
The purpose of this study is to contrast the relative efficacy of Carotid Artery Stenting versus Carotid Endarterectomy in 1) preventing stroke, myocardial infarction, and death during a 30-day periprocedural period, and 2) ipsilateral stroke to the study artery over the follow-up period in patients with symptomatic and asymptomatic extracranial carotid stenosis.
Genetic Modifiers in Cystic Fibrosis Lung Disease
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Researchers are interested in studying DNA blood samples from people with CF to determine if other non-CF genes (modifiers) may contribute to severity or mildness of CF lung disease. Identifying genetic modifiers that influence lung disease severity may ultimately lead to a better understanding of cystic fibrosis, and may be useful in developing new treatments.
